Mayapur is believed to be the birthplace of Chaitanya Mahaprabhu, the 16th century Hindu saint, who was also the initiator of the Bhakti Movement. Thus, the place was central to the Gaudiya Vaishnava philosophy. The pilgrimage spot owes its rapid growth to Srila Prabhupada, the one who established ISKCON. Srila Prabhupada always wanted to make a spiritual home in the Dham for his students and this desire brought him back to India from the West, where he was occupied in preaching Krishna consciousness.

Mayapur according to Srila Prabhupada is the epicenter of a global spiritual renaissance. This would be a way through which man can go back to a better God-centered way of life.

In Sri Mayapur, Srila Prabhupada firstly achieved a guesthouse. It was his utmost 

desire to facilitate the pilgrims and visitors who flock to Mayapur, with great convenience and comfort. He wanted to ensure shelter and nourishment to the spiritually hungry souls who came to Mayapur or according to Srila Prabhupada, the holiest of places.

Following Srila Prabhupada's death, many more guesthouses have been erected here. Apart from the guesthouses, Mayapur now also flaunts a restaurant, Prasadam hall, schools, shops and a cowshed.